Restylane® Defyne is specially formulated to smooth out deep laugh lines.

As skin loses elasticity over time, the lines that run from the sides of your nose toward the corners of your mouth and the lines that run from the corner of your mouth toward the chin may appear more pronounced.

Restylane Defyne may help correct these deepened lines for a more natural look to your face.3. The unique cross-linking of the gel in Restylane Defyne is designed to help support your facial expressions for natural-looking results that help maintain your natural movement.1,2

Maintain Natural Movement & Expression

Restylane Refyne and Restylane Defyne are the only fillers on the market that have been shown in clinical trials to help maintain natural movement and expressions.1,2,4

What happens as we age?

  • Hyaluronic acid (HA) is a naturally occurring substance in your skin that helps provide fullness and elasticity
  • As we age, skin loses HA
  • As HA diminishes, skin loses volume, increasing chances for wrinkles and folds to appear

The good news is that you can do something about it. You can use products in the Restylane® family to restore HA.5 Products in the Restylane family are used to add volume and fullness to the skin to correct moderate to severe facial wrinkles and folds such as the lines from your nose to the corners of your mouth (nasolabial folds). Restylane is also the first and only FDA-approved dermal filler for lip enhancement in patients over 21 years.6

About the Restylane Regimen

What is the Restylane Regimen? It’s a way to help you get the most out of your Restylane treatments. The Restylane Regimen is a treatment plan that involves an initial treatment and a follow-up treatment 4.5 or nine months later. On average, only half the amount of Restylane injectable gel used at the initial treatment was needed to achieve full correction at the follow-up treatment.

Restylane is the only hyaluronic acid dermal filler approved to last up to 18 months from initial treatment of moderate to severe nasolabial folds (lines from the nose to the corners of the mouth) when patients followed the Restylane Regimen.

With Restylane injectable gel, time is on your side

At least 95% of patients saw results for up to 18 months when they followed the Restylane Regimen.

In a clinical study treating the lines from the nose to the corners of the mouth (laugh lines), Restylane continued to provide improvement for up to 18 months after initial treatment, when each line received a follow-up treatment at 4.5 or nine months.5

Using the Restylane Regimen, patients showed similar improvement, on average, at 18 months compared to their Week 2 Wrinkle Severity Rating Scale (WSRS) score.

*Results are not guaranteed and your results may vary.